Gluten: What You Need to Know

Hippocrates: “All disease begins in the gut.”

Gluten is a controversial topic these days. To cut to the chase, gluten can affect nearly every tissue in the body, including the brain, skin, endocrine system, stomach, liver, blood vessels, smooth muscles, and even the nuclei of cells. What is it? It’s one of several proteins that is found in wheat. Gliadins and glutenins are the two main components of the gluten fraction of the wheat seed. Basically, these components are what allow breads to rise during baking and to preserve foods in many cases. Within the gliadin class of wheat, there are four different types of proteins, which are alpha-, beta-, gamma-, and omega-gliadin. Wheat also contains agglutinins, which are proteins that bind to sugar, and prodynorphins, which are proteins involved with cellular communication. Once wheat is consumed, up to 6 different enzymes in the digestive tract called tissue transglutaminases (tTG) break down the wheat compound and forms additional proteins. Are you still reading? I promise it’s useful information…

Most people assume that if you don’t have Celiac’s Disease, then you don’t need to worry about including gluten in your diet or going gluten-free. Celiac’s Disease is an autoimmune disease characterized by an inflammatory immune response to wheat gluten, rye, barley, and related proteins. It results in the disruption of the normal gut tissue structure, including atrophy of the villi and an enlargement of intestinal crypts where new epithelial cells form from stem cells. However, it’s not so black and white. The problem with testing for Celiac’s Disease is that the test only tests for the alpha-gliaden and transglutaminase 2 (tTG2). Remember, there are 4 different types of proteins found in wheat and 6 different enzymes, which means there is a lot of room for error or misdiagnosis. Basically, you’ll test negative for Celiac’s Disease and gluten intolerance no matter how severely you’re reacting to wheat. There is a spectrum that can range from being completely gluten-tolerant to suffering from full-blown Celiac’s Disease. On this spectrum, there is a term that broadly covers a whole range of conditions/symptoms related to gluten and wheat.

This term is called Non-Celiac Gluten Sensitivity, or NCGS. NCGS is a response to wheat or gluten ingestion, but in the form of gut discomfort, systemic pain, fatigue, neurological issues, and worsening of autoimmune conditions. Research demonstrates that nearly 1 out of every 10 individuals can have Non-Celiac Gluten Sensitivity. Here’s a list of conditions linked to NCGS:

  • Irritable bowel syndrome
  • Fibromyalgia
  • Dermatitis and other skin conditions
  • Multiple sclerosis
  • Peripheral neuropathy, myopathy, and other neurological disorders
  • Schizophrenia
  • Depression
  • ADHD
  • Ataxia
  • Type 1 diabetes
  • Autism spectrum disorders
  • Ménière disease
  • Endometriosis
  • Insulin resistance and inflammation

This is reason enough to avoid gluten and wheat all together, in my opinion. However, here is the best way determine if you have gluten intolerance or wheat intolerance:

  1. Remove all gluten-containing foods and products from your diet for 60 days
  2. At the end of the 60 day period, cook up a bowl of barley (gluten-containing), eat it, and see what happens.

3.   A few days later, eat a piece of wheat bread. See what happens.

If you react to barley, that suggests you’re intolerant of gluten or other gluten-like compounds. If you don’t react to barley, but you do react to the wheat bread, that suggests you are intolerant to something in wheat specifically. 

To be clear, not all disease is caused by gluten. There are certainly other health conditions that could cause gluten intolerance or Celiac’s Disease. However, there are many links between gluten and other health conditions. If you suffer from chronic pain, autoimmune conditions, digestive issues, and arthritis, then replacing gluten and wheat with more vegetables and good quality fats and proteins could help ease your symptoms.

To give an you example of how you can still “have your cake and eat it, too”, here’s a banana bread muffin that is gluten free. This particular muffin is made with buckwheat. Don’t let the name fool you, though. Buckwheat is gluten free and has a generous amount of antioxidants and nutrients. Other options you could use to replace wheat are almond flour, gluten free oats, or rice/potato flour. 

In Health,

Adam and Feier

References

  1. https://pubmed.ncbi.nlm.nih.gov/2720800/
  2. https://pubmed.ncbi.nlm.nih.gov/11673371/
  3. https://pubmed.ncbi.nlm.nih.gov/11738475/
  4. https://pubmed.ncbi.nlm.nih.gov/18825674/
  5. https://pubmed.ncbi.nlm.nih.gov/20170845/
  6. https://pubmed.ncbi.nlm.nih.gov/24077239/
  7. https://pubmed.ncbi.nlm.nih.gov/24369326/

Sugar and Inflammation

Sugar…a word that alarms many people. “We need it to survive…No, we don’t need it…go keto…go vegan…blah, blah, blah.”

I want to clear up some confusion in this blog about sugar and why we choose to limit the amount of sugar we use in our baking. To be clear, our bodies will make their own sugar to survive. We don’t necessarily need sugar in our diets to survive. It’s just how the body works. There are also many different types of sugar such as glucose, fructose, sucrose, high fructose corn syrup, fruit sugar, nectar, honey…the list goes on. 

So, why do we choose to avoid the use of sugar in Barefoot Baking goods? I’ll just provide some reasons in list form. Sugar…

  • Stimulates a physiological stressor-reaction cascade that provokes adrenaline and cortisol release …and thickens the blood.
  • Effectively disables your immune system by impairing white blood cells’ functioning.
  • Decreases your body’s production of leptin, a hormone critical for appetite regulation…That’s why you always want more!
  • Induces significant oxidative stress in the body, which increases aging.
  • Appears to fuel cancer cells.
  • Promotes fat storage, weight gain, and obesity.
  • Disrupts the effective transfer of amino acids to muscle tissue.
  • Intake over time spurs insulin resistance, subsequent Type II Diabetes, and an entire host of related health issues such as nerve damage, cardiovascular disease, gut problems, and more inflammatory conditions.
  • Is addictive.

Sugar was a reward for us “back in the day”…meaning our ancestors found it very valuable. We looked at sugar as a high caloric density food because we never knew when our next meal would come. However, we only had access to sugar during different seasons. There were no grocery stores available to us on every corner. The consumption of such foods promoted the storage of body fat, which in turn enabled us to survive periods of famine. However, in the modern world, very few of us experience hunger. Instead, most of us have constant access to sugary, processed foods. When consumed in excess, the health conditions mentioned above may manifest. This biological wiring (sugar as a reward) is what results in the addictive, opiate-like property of sugar (2, 3).

Excess sugar intake can lead to Type II Diabetes, which is characterized by insulin resistance. Insulin resistance is when our cells don’t respond as strongly to insulin, and you need more to produce the desired effect. Our pancreas releases insulin in response to sugar (and other things like cortisol) to lower your blood glucose levels after eating. In fact, postprandial blood glucose, meaning post-meal blood glucose, is the most common way to diagnose Type II Diabetes. If it’s too high, that’s considered hyperglycemia. Type II Diabetes is your body’s way of saying your pancreas is tired. Hyperinsulinemia means our insulin levels are always elevated. This inhibits you from releasing fatty acids from your body fat to be burned for energy. 

The bacteria that inhabits our gut thrive on carbohydrates, which is good and bad. Complex carbohydrates, such as soluble fiber found in starchy plants like squash or sweet potatoes, feed beneficial gut bacteria, boost anti-inflammatory gut microbiota, and discourage the growth of opportunistic and pathogenic bacteria. This is good. The consumption of processed carbohydrates and refined sugar found in less nutritious foods, however, triggers the growth of harmful gut bacteria and promotes an inflammatory gut microbiota. This is bad…and sad (1). Because the health of our gut determines the health of our immune system, excess sugar intake can lead to an impaired immune response. This can increase risk of some autoimmune conditions, pain, skin rashes or acne, and other inflammatory conditions (4). Diets high in sugar can also lead to an increase risk of cardiovascular disease, high blood pressure, and coronary heart disease (5).

Perhaps, the most important reason we choose to bake without excess sugar is due to sugar’s likelihood of promoting cancer growth (6). Why exactly does sugar promote cancer growth? It turns out that cancerous cells can rewire their metabolism so that they become very efficient at taking up glucose from the bloodstream to use as fuel. This is known as the Warburg Effect. Diets high in refined sugar and other processed carbohydrates supply the body with large amounts of glucose, creating an environment conducive to cancer growth. We like to use raw honey if we want a “bit of sweet”, but honey is a real, natural food. Honey is delicious, and it has also been proven to have numerous health benefits. Raw honey has antibacterial effects against gut pathogens such as Salmonella, E. coli, and Shigella, as well as, the periodontal pathogen Porphyromonas gingivalis. It is also a good source of prebiotics that promote the growth of Lactobacillus and Bifidobacteria. Honey offers some cardiovascular benefits, as well, because it has antioxidant effects and improves the function of the endothelium of the heart (8, 9)! However, don’t go drinkin’ a bottle of honey…that wouldn’t be good. There’s still sugar in honey, so use it in moderation.

Most of the time, we like to stay as low-carb, low sugar, or keto as possible. The reason being is that the ketogenic diet has been proven useful as an adjunct treatment for cancer in a handful of studies (7). The ketogenic diet is a high-fat, moderate protein, very-low-carbohydrate diet that significantly reduces blood sugar and causes the body to rely on ketones, rather than glucose, for energy. Remember the Warburg Effect above? This is essentially the opposite of that! 

I hope this helps in understanding sugar and why we like to avoid it. Please see the references below for more info!

In Health,

Adam

  1. https://pubmed.ncbi.nlm.nih.gov/23016134/
  2. https://pubmed.ncbi.nlm.nih.gov/28747384/
  3. https://pubmed.ncbi.nlm.nih.gov/29052153/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448089/
  5. https://pubmed.ncbi.nlm.nih.gov/26586275/
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783224/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842847/
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549483/
  9. https://pubmed.ncbi.nlm.nih.gov/24666777